MUC4 antibody (AA 1730-1864)

Catalog No. ABIN6937955

Product Details anti-MUC4 Antibody

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Binding Specificity: AA 1730-1864

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUC4 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)

Clone: MUC4-3105

Isotype: IgG2b kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Stomach, Colon or esophagus.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Alternative Name: MUC4 (MUC4 Products)

Synonyms: 4933405I11Rik antibody, Asgp antibody, ASGP antibody, HSA276359 antibody, MUC-4 antibody, ASGP-1 antibody, Psmc antibody, mucin 4 antibody, mucin 4, cell surface associated antibody, Muc4 antibody, MUC4 antibody

Background: Ascites sialoglycoprotein 1, Ascites sialoglycoprotein 2, Ascites sialoglycoprotein, ASGP, ASGP-1, ASGP-2, Mucin 4 cell surface associated, Mucin-4 beta chain, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin,MUC4 (Mucin 4 / Gastric Mucin)
Cellular localisation: Cytoplasmic

Molecular Weight: 235kDa

Gene ID: 4585, 369646

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity