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MUC4 antibody (AA 1730-1864)

MUC4 Reactivity: Human IHC (f) Host: Mouse Monoclonal MUC4-3084 unconjugated
Catalog No. ABIN6937954
  • Target See all MUC4 Antibodies
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Binding Specificity
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1730-1864
    Reactivity
    • 37
    • 13
    • 3
    Human
    Host
    • 30
    • 8
    Mouse
    Clonality
    • 22
    • 16
    Monoclonal
    Conjugate
    • 22
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This MUC4 antibody is un-conjugated
    Application
    • 21
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)
    Clone
    MUC4-3084
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MUC4 Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Stomach, Colon or esophagus.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Alternative Name
    MUC4 (MUC4 Products)
    Synonyms
    4933405I11Rik antibody, Asgp antibody, ASGP antibody, HSA276359 antibody, MUC-4 antibody, ASGP-1 antibody, Psmc antibody, mucin 4 antibody, mucin 4, cell surface associated antibody, Muc4 antibody, MUC4 antibody
    Background
    Ascites sialoglycoprotein 1 / 2, ASGP, ASGP-1, ASGP-2, MUC-4, MUC4, Mucin 4 cell surface associated, Mucin 4 tracheobronchial, Mucin-4 beta chain, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin,MUC4 (Mucin 4 / Gastric Mucin)
    Cellular localisation: Cytoplasmic
    Molecular Weight
    235kDa
    Gene ID
    4585, 369646
    UniProt
    Q99102
    Pathways
    Regulation of Leukocyte Mediated Immunity
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