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Recombinant IgL antibody

Reactivity: Human IHC (f) Host: Rabbit Monoclonal LLC-3778R unconjugated Recombinant Antibody
Catalog No. ABIN6937552
  • Target See all IgL products
    IgL
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 10
    • 2
    Rabbit
    Clonality
    • 11
    • 1
    Monoclonal
    Conjugate
    • 11
    • 1
    This IgL antibody is un-conjugated
    Application
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length human IGL protein
    Clone
    LLC-3778R
    Isotype
    IgG
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: 293T, Raji or hPBL cells. Tonsil or Spleen.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    IgL
    Abstract
    IgL Products
    Synonyms
    IGL@ antibody, IGLC6 antibody, igl antibody, immunoglobulin lambda locus antibody, IGL antibody, igl@ antibody
    Background
    Bence Jones Protein, BJP, IGLC 1/2/3, Mcg Marker, Paraprotein,Lambda Light Chain (B-Cell Marker)
    Cellular localisation: Cell Surface, cytoplasmic and secreted
    Molecular Weight
    ~22.5kDa
    Gene ID
    3535, 3546, 449585
    UniProt
    P01701, P01842
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