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Recombinant IGHG4 antibody

IGHG4 Reactivity: Human ISt, IHC (f) Host: Mouse Monoclonal rIGHG4-1345 unconjugated Recombinant Antibody
Catalog No. ABIN6937505
  • Target See all IGHG4 products
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 15
    • 1
    • 1
    Human
    Host
    • 11
    • 4
    Mouse
    Clonality
    • 10
    • 5
    Monoclonal
    Conjugate
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    This IGHG4 antibody is un-conjugated
    Application
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant human IGHG4 fragment
    Clone
    RIGHG4-1345
    Isotype
    IgG1 kappa
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Positive_Control: Tonsil.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Alternative Name
    IGHG4 (IGHG4 Products)
    Synonyms
    immunoglobulin heavy constant gamma 4 (G4m marker) antibody, IGHG4 antibody
    Background
    Ig gamma 4 chain C region, IGHG4, Immunoglobulin heavy constant gamma 4 (G4m marker),IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker)
    Cellular localisation: Cytoplasmic
    Molecular Weight
    150kDa
    Gene ID
    3503, 510635
    UniProt
    P01861
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