Recombinant Desmocollin 2 antibody

Catalog No. ABIN6937105

Product Details anti-Desmocollin 2 Antibody

Target: Desmocollin 2 (DSC2)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmocollin 2 antibody is un-conjugated

Application: ELISA, Coating (Coat)

Specificity: Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.

Cross-Reactivity (Details): Human. Mouse. Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human DSC2 protein

Clone: RDSC2-3437

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Skin tissue.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for Desmocollin 2

Target: Desmocollin 2 (DSC2)

Alternative Name: DSC2 (DSC2 Products)

Synonyms: ARVD11 antibody, CDHF2 antibody, DG2 antibody, DGII/III antibody, DSC3 antibody, AW228162 antibody, Dsc2a antibody, Dsc2b antibody, DSC2 antibody, desmocollin 2 antibody, DSC2 antibody, Dsc2 antibody

Background: ARVD11, Cadherin family member 2, CDHF2, Desmocollin-2, Desmocollin-3, Desmosomal glycoprotein II and III, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DG2, DGII/III, DSC2, DSC3,Desmocollin-2/3
Cellular localisation: Cell surface

Molecular Weight: 110kDa (DSC2), 100kDa (DSC3)

Gene ID: 1824, 95612

UniProt: Q02487