Complement 3d (C3d) (Acute Humoral Rejection Marker) antibody

Catalog No. ABIN6937012

Product Details

Target: Complement 3d (C3d) (Acute Humoral Rejection Marker)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Coating (Coat), ELISA

Purification: Purified by Protein A/G

Immunogen: Recombinant full-length human Complement C3 protein

Clone: C3D-2891

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: Human kidney or rejected renal transplant tissue.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Buffer: 10 mM PBS without BSA and without Azide.

Preservative: Azide free

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.

Expiry Date: 24 months

Target Details

Target: Complement 3d (C3d) (Acute Humoral Rejection Marker)

Background: The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH - and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.

Molecular Weight: 35kDa (predicted)

Gene ID: 718

UniProt: P01024