CD46 antibody (AA 251-355)
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- Target See all CD46 Antibodies
- CD46
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Binding Specificity
- AA 251-355
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CD46 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human, Mouse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from Mouse CD46
- Isotype
- IgG
- Top Product
- Discover our top product CD46 Primary Antibody
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anti-CD46 (CD46) (AA 35-179) antibody
CD46 Reactivity: Human FACS, ELISA, IHC Host: Mouse Monoclonal 1A5A5 unconjugated
anti-CD46 (CD46) (AA 40-320) antibodyCD46 Reactivity: Human WB, IF, IHC Host: Rabbit Polyclonal unconjugated
anti-CD46 (CD46) (AA 317-343) antibodyCD46 Reactivity: Human WB, FACS, IF, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-CD46 (CD46) antibodyCD46 Reactivity: Human, Cow WB, FACS, IP Host: Mouse Monoclonal MEM-258 unconjugated
anti-CD46 (CD46) antibodyCD46 Reactivity: Human, Cow WB, FACS, IP Host: Mouse Monoclonal MEM-258 unconjugated
anti-CD46 (CD46) (AA 317-343), (C-Term) antibodyCD46 Reactivity: Human WB, FACS, IF, IHC (p) Host: Rabbit Polyclonal RB21743 unconjugated
anti-CD46 (CD46) antibodyCD46 Reactivity: Human WB, ELISA, IHC Host: Rabbit Monoclonal 7D12 unconjugated Recombinant Antibody
anti-CD46 (CD46) antibody (Biotin)CD46 Reactivity: Human, Cow WB, FACS, IP Host: Mouse Monoclonal MEM-258 Biotin
anti-CD46 (CD46) antibody (FITC)CD46 Reactivity: Human, Cow FACS Host: Mouse Monoclonal MEM-258 FITC
anti-CD46 (CD46) antibody (APC)CD46 Reactivity: Human, Cow FACS Host: Mouse Monoclonal MEM-258 APC
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- CD46
- Alternative Name
- CD46/MCP (CD46 Products)
- Background
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Synonyms: MCP, TLX, AHUS2, MIC10, TRA2.10, Membrane cofactor protein, Trophoblast leukocyte common antigen, CD46
Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- Gene ID
- 4179
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
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