RBBP6 antibody (AA 2-150) (Biotin)

Catalog No. ABIN687204

Product Details anti-RBBP6 Antibody (Biotin)

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Binding Specificity: AA 2-150

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBBP6 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human P2PR

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for RBBP6

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Alternative Name: RBBP6/P2P-R (RBBP6 Products)

Synonyms: MY038 antibody, P2P-R antibody, PACT antibody, RBQ-1 antibody, SNAMA antibody, 4933422O15Rik antibody, AI316869 antibody, BB233631 antibody, C030034J04Rik antibody, C77662 antibody, rbbp6 antibody, MGC75882 antibody, RBBP6 antibody, im:7158869 antibody, rbbp6l antibody, RB binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6 antibody, RBBP6 antibody, Rbbp6 antibody, rbbp6 antibody

Background:

Synonyms: PACT, MY038, P2P-R, RBQ-1, SNAMA, E3 ubiquitin-protein ligase RBBP6, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, Retinoblastoma-binding protein 6, p53-associated cellular protein of testis, RBBP6, P2PR, RBQ1

Background: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.

Gene ID: 5930

UniProt: Q7Z6E9

Pathways: Regulatory RNA Pathways