CD177 antibody (AA 521-650)

Catalog No. ABIN687187

Product Details anti-CD177 Antibody

Target: CD177 (CD177 Molecule (CD177))

Binding Specificity: AA 521-650

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD177 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat CD177

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CD177 antibody (ABIN687187)

Ning, Yang, Chen, Tian, Zhao, Zhang, Liu, Li, Zhao, Peng, Wang, Chen, Zhou: "Caffeine attenuates brain injury but increases mortality induced by high-intensity blast wave exposure." in: Toxicology letters, Vol. 301, pp. 90-97, (2019) (PubMed).

Yang, Chi, Liu, Yang, Shen, Yang: "Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis." in: Journal of cellular and molecular medicine, (2015) (PubMed).

Scott, Klutho, El Accaoui, Nguyen, Venema, Xie, Jiang, Dibbern, Scroggins, Prasad, Luczak, Davis, Li, Guan, Backs, Schlueter, Weiss, Miller, Anderson, Grumbach: "The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling." in: PLoS ONE, Vol. 8, Issue 8, pp. e71550, (2013) (PubMed).

Li, Li, Sanders, Mohler, Backs, Olson, Anderson, Grumbach et al.: "The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle ..." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 7990-9, (2011) (PubMed).

Target Details for CD177

Target: CD177 (CD177 Molecule (CD177))

Alternative Name: CD177/NB1 (CD177 Products)

Synonyms: HNA-2a antibody, HNA2A antibody, NB1 antibody, NB1 GP antibody, PRV-1 antibody, PRV1 antibody, RGD1562941 antibody, CD177 antibody, MGC157159 antibody, 1190003K14Rik antibody, Pdp3 antibody, CD177 molecule antibody, CD177 antigen antibody, CD177 antibody, Cd177 antibody

Background:

Synonyms: NB1 GP,PRV-1,HNA-2a,NB1 glycoprotein,Neutrophil Glycoprotein NB1, RGD1562941, CD177 antigen, Polycythemia rubra vera protein 1, PRV-1, NB1 glycoprotein, NB1 GP, Human neutrophil alloantigen 2a, HNA-2a, CD177, CD177_HUMAN, CD177_MOUSE.

Background: Cd177 (NP1), a glycosyl phosphatidylinositol (GPI) linked N glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia and analyses showed cell surface expression of a 60 kDa protein, 14 kDa greater than the predicted size, probably due to the presence of 3 potential N glycosylation sites. Immunohistochemistry demonstrated expression in bone marrow early erythroblasts, megakaryocytes, promyelocytes, and myelocytes. The neutrophil NB1 antigen (CD177) is expressed by 97 % of the caucasian population. against NB1 can be involved in neonatal alloimmune neutropenia (NAN).

Gene ID: 499099

UniProt: D3ZCH9