ARFIP2 antibody (AA 221-341) (Biotin)

Catalog No. ABIN686589

Product Details anti-ARFIP2 Antibody (Biotin)

Target: ARFIP2 (ADP-Ribosylation Factor Interacting Protein 2 (ARFIP2))

Binding Specificity: AA 221-341

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARFIP2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Arfaptin 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ARFIP2

Target: ARFIP2 (ADP-Ribosylation Factor Interacting Protein 2 (ARFIP2))

Alternative Name: Arfaptin 2 (ARFIP2 Products)

Synonyms: POR1 antibody, 2310002N04Rik antibody, POR antibody, Por1 antibody, ARFIP2 antibody, im:7136059 antibody, zgc:112066 antibody, ADP ribosylation factor interacting protein 2 antibody, ADP-ribosylation factor interacting protein 2 antibody, ADP-ribosylation factor interacting protein 2b antibody, ARFIP2 antibody, Arfip2 antibody, arfip2b antibody

Background:

Synonyms: ARFIP2, arfaptin 2, ADP-ribosylation factor interacting protein 2, Partner of RAC1, POR1, ARFP2_HUMAN .

Background: ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes.

Gene ID: 23647