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AKAP12 antibody (AA 701-900)

AKAP12 Reactivity: Rat, Mouse WB, ELISA, IHC (p), IHC (fro), FACS, IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN685732
  • Target See all AKAP12 Antibodies
    AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))
    Binding Specificity
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 701-900
    Reactivity
    • 22
    • 4
    • 2
    • 2
    Rat, Mouse
    Host
    • 19
    • 3
    • 2
    • 2
    Rabbit
    Clonality
    • 25
    • 1
    Polyclonal
    Conjugate
    • 19
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AKAP12 antibody is un-conjugated
    Application
    • 13
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Dog
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human of human AKAP12
    Isotype
    IgG
    Top Product
    Discover our top product AKAP12 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))
    Alternative Name
    AKAP12/Gravin (AKAP12 Products)
    Synonyms
    akap12 antibody, cb27 antibody, esr1 antibody, fb72g12 antibody, id:ibd1202 antibody, sb:cb27 antibody, si:ch73-192g21.1 antibody, wu:fb72g12 antibody, wu:fc21c03 antibody, AKAP12 antibody, AI317366 antibody, SSeCKS antibody, Srcs5 antibody, Tsga12 antibody, AKAP12A antibody, AKAP12B antibody, AKAP12G antibody, AKAP250 antibody, A kinase (PRKA) anchor protein 12b antibody, A-kinase anchoring protein 12 antibody, A kinase (PRKA) anchor protein (gravin) 12 antibody, akap12b antibody, AKAP12 antibody, Akap12 antibody
    Background

    Synonyms: A kinase PRKA anchor protein gravin 12, A kinase Anchor Protein 12, A kinase anchor protein 250 kDa, AKAP 12, AKAP 250, AKAP250, DKFZp686M0430, DKFZp686O0331, Gercelin, Gravin, Kinase scaffold protein gravin, Myasthenia gravis autoantigen gravin, Srcs5, SSeCKS, Tsga12.

    Background: Gravin (also known as A Kinase Anchor Protein 12, AKAP12) was cloned from a cDNA expression library screened with serum, from a myasthenia gravis patient. to Gravin were found in 22 out of 72 myasthemia gravis patients and absent in sera of normal individuals. This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts and osteosarcoma cells and highly expressed in the brain. Gravin can bind kinases like PKA and PKC by different domains of the protein and can localize these kinases to specific domains in the cell. Upon differentiation of NT2 cells to neurons (NT2 N), Gravin expression is up regulated and enriched at the inner peripheral cortex in close proximity to the plasma membrane. In differentiated cells, gravin is co-localized with PKCbII, PKCa and PKA. Decreased binding of PKCa to gravin was found after activation of PKC.

    Gene ID
    9590
    Pathways
    cAMP Metabolic Process
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