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Merlin antibody (AA 401-550)

NF2 Reactivity: Human, Rat WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN685522
  • Target See all Merlin (NF2) Antibodies
    Merlin (NF2) (Neurofibromin 2 (NF2))
    Binding Specificity
    • 29
    • 14
    • 9
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-550
    Reactivity
    • 77
    • 66
    • 55
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human, Rat
    Host
    • 88
    • 4
    • 1
    Rabbit
    Clonality
    • 91
    • 2
    Polyclonal
    Conjugate
    • 47
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Merlin antibody is un-conjugated
    Application
    • 71
    • 31
    • 26
    • 25
    • 20
    • 16
    • 11
    • 10
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NF2
    Isotype
    IgG
    Top Product
    Discover our top product NF2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    Merlin (NF2) (Neurofibromin 2 (NF2))
    Alternative Name
    NF2/Neurofibromin 2 (NF2 Products)
    Synonyms
    ACN antibody, BANF antibody, SCH antibody, NF2 antibody, merlin antibody, zgc:194620 antibody, zgc:194631 antibody, NF2a antibody, nf2 antibody, neurofibromin 2 antibody, neurofibromin 2a (merlin) antibody, neurofibromin 2b (merlin) antibody, neurofibromin 2 (merlin) S homeolog antibody, NF2 antibody, Nf2 antibody, nf2a antibody, nf2b antibody, nf2.S antibody
    Background

    Synonyms: ACN, SCH, BANF, Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin, NF2

    Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

    Gene ID
    4771
    UniProt
    P35240
    Pathways
    Cell-Cell Junction Organization
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