SRPK1 antibody (AA 551-655)

Catalog No. ABIN681748

Product Details anti-SRPK1 Antibody

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Binding Specificity: AA 551-655

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SRPK1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SRPK1

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Alternative Name: SRPK1 (SRPK1 Products)

Synonyms: SFRSK1 antibody, AU017960 antibody, BEST:CK01209 antibody, CG11489 antibody, CG9085 antibody, CK01209 antibody, Dmel\\CG11489 antibody, SRPK antibody, SRPK1 antibody, Srpk79D antibody, atc antibody, srpk1 antibody, zgc:63789 antibody, wu:fc06h03 antibody, zgc:158800 antibody, sfrsk1 antibody, SRSF protein kinase 1 antibody, serine/arginine-rich protein specific kinase 1 antibody, Serine-arginine protein kinase at 79D antibody, SRSF protein kinase 1a antibody, SRSF protein kinase 1b antibody, SRSF protein kinase 1 S homeolog antibody, SRPK1 antibody, Srpk1 antibody, Srpk79D antibody, srpk1a antibody, srpk1b antibody, srpk1.S antibody

Background:

Synonyms: Serine/arginine rich protein specic kinase 1, Serine/arginine-rich protein-specic kinase 1, Serine/threonine protein kinase SRPK1, Serine/threonine-protein kinase SRPK1, SFRS protein kinase 1, SR protein kinase 1, SR protein specic kinase 1, SR-protein-specic kinase 1, SRPK1, SRPK1_HUMAN.

Background: Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.

Gene ID: 6732

Pathways: Toll-Like Receptors Cascades