PKD2 antibody (AA 651-750) (Biotin)

Catalog No. ABIN678100

Product Details anti-PKD2 Antibody (Biotin)

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Binding Specificity: AA 651-750

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody may have a minor secondary cross-reactivity towards Polycystin 2-like protein 1 due to a 71 % non-contiguous sequence similarity in the immunogen sequence.

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Polycystin 2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Alternative Name: Polycystin 2 (PKD2 Products)

Synonyms: APKD2 antibody, PC2 antibody, PKD4 antibody, Pc-2 antibody, TRPP2 antibody, C030034P18Rik antibody, RGD1559992 antibody, pkd2 antibody, trpp2 antibody, Cup antibody, PKD2L1 antibody, polycystin 2, transient receptor potential cation channel antibody, polycystic kidney disease 2 antibody, Polycystin-2 antibody, polycystin 2, transient receptor potential cation channel L homeolog antibody, PKD2 antibody, Pkd2 antibody, pkd-2 antibody, pkd2.L antibody, pkd2 antibody

Background:

Synonyms: PC2, PKD4, Pc-2, APKD2, TRPP2, Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, Transient receptor potential cation channel subfamily P member 2, PKD2

Background: Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).

Gene ID: 5311

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity