PKD1 antibody (AA 131-230)

Catalog No. ABIN678083

Product Details anti-PKD1 Antibody

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Binding Specificity: AA 131-230

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Polycystin 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-PKD1 antibody (ABIN678083)

Ren, Xia, Yang, Zhu, Zhang, Chen, Zhao, Sun, Zhao: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." in: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).

Kito, Saigo, Takeuchi: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." in: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).

Ohata, Herranz-Pérez, Nakatani, Boletta, García-Verdugo, Álvarez-Buylla: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).

Chiou, Sang, Cheng, Ho, Wang, Pan: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." in: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).

Target Details for PKD1

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Alternative Name: Polycystin 1 (PKD1 Products)

Synonyms: PBP antibody, Pc-1 antibody, TRPP1 antibody, PC1 antibody, mFLJ00285 antibody, polycystin 1, transient receptor potential channel interacting antibody, polycystin 1, transient receptor poteintial channel interacting antibody, polycystin-1 antibody, PKD1 antibody, Pkd1 antibody, LOC749291 antibody

Background:

Synonyms: PBP, Pc-1, TRPP1, Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1

Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Gene ID: 5310

UniProt: P98161

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location