Menin antibody (AA 501-615)
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- Target See all Menin (MEN1) Antibodies
- Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))
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Binding Specificity
- AA 501-615
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Menin antibody is un-conjugated
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Application
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Dog,Cow,Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Menin
- Isotype
- IgG
- Top Product
- Discover our top product MEN1 Primary Antibody
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- Application Notes
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))
- Alternative Name
- Menin (MEN1 Products)
- Synonyms
- MEAI antibody, SCG2 antibody, menin antibody, meai antibody, scg2 antibody, AW045611 antibody, menin 1 antibody, menin 1 L homeolog antibody, multiple endocrine neoplasia I antibody, multiple endocrine neoplasia 1 antibody, MEN1 antibody, men1 antibody, men1.L antibody, Men1 antibody
- Background
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Synonyms: MEAI, SCG2, Menin, MEN1
Background: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
- Gene ID
- 4221
- UniProt
- O00255
- Pathways
- Chromatin Binding, Positive Regulation of Endopeptidase Activity
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