Reticulon 4 antibody (AA 251-357)
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- Target See all Reticulon 4 (RTN4) Antibodies
- Reticulon 4 (RTN4)
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Binding Specificity
- AA 251-357
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Reticulon 4 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- Based on the location of the target sequence this antibody will recognize all isoforms(Nogo-A, Nogo-B, and Nogo-C).
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Dog,Sheep
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from Mouse Reticulon 4
- Isotype
- IgG
- Top Product
- Discover our top product RTN4 Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- Reticulon 4 (RTN4)
- Alternative Name
- Reticulon 4 (RTN4 Products)
- Background
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Synonyms: Reticulon-4, Rtn4, Neurite outgrowth inhibitor, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, euroendocrine-specific protein C homolog, RTN-x, Reticulon-5, RTN 4A, Nogo-A, RTN-xL, RTN 4B, ASY, Nogo-B, RTN-xS, Foocen-M, RTN 4C, Nogo-C, Foocen-S, RTN4-B2, Rtn-T
Background: Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The reticulon protein is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon 4 regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.
- Gene ID
- 68585
- UniProt
- Q99P72
- Pathways
- Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome
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