ADAM8 antibody (AA 70-119)

Catalog No. ABIN6746715

Product Details anti-ADAM8 Antibody

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Binding Specificity: AA 70-119

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM8 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Human ADAM8

Predicted Reactivity: Percent identity by BLAST analysis: Human (100%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide located between aa70-119 of human ADAM8 (NP_001100). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%), Mouse (78%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: WB (0.2 - 1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS with 2 % sucrose

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.

References for anti-ADAM8 antibody (ABIN6746715)

Barbara, Wrana, Letarte: "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 584-94, (1999) (PubMed).

Li, Sorensen, Brooke, Urness, Davis, Taylor, Boak, Wendel: "Defective angiogenesis in mice lacking endoglin." in: Science (New York, N.Y.), Vol. 284, Issue 5419, pp. 1534-7, (1999) (PubMed).

Bellón, Corbí, Lastres, Calés, Cebrián, Vera, Cheifetz, Massague, Letarte, Bernabéu: "Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions." in: European journal of immunology, Vol. 23, Issue 9, pp. 2340-5, (1993) (PubMed).

Gougos, Letarte: "Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells." in: The Journal of biological chemistry, Vol. 265, Issue 15, pp. 8361-4, (1990) (PubMed).

Target Details for ADAM8

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Alternative Name: ADAM8 (ADAM8 Products)

Synonyms: CD156 antibody, MS2 antibody, CD156a antibody, E430039A18Rik antibody, adam8 antibody, reprolysin antibody, si:zc217g15.7 antibody, zgc:64059 antibody, ADAM8 antibody, RGD1566394 antibody, ADAM metallopeptidase domain 8 antibody, a disintegrin and metalloproteinase domain 8 antibody, a disintegrin and metallopeptidase domain 8 antibody, ADAM metallopeptidase domain 8a antibody, ADAM8 antibody, LOC100304737 antibody, Adam8 antibody, adam8a antibody, adam8 antibody

Background: Name/Gene ID: ADAM8
Subfamily: Metallopeptidase M12B
Family: Protease

Synonyms: ADAM8, ADAM metallopeptidase domain 8, Cell surface antigen MS2, ADAM 8, MS2, CD156, CD156a antigen

Gene ID: 101

NCBI Accession: NP_001100

UniProt: P78325

Pathways: Activation of Innate immune Response, M Phase