CHRM3 antibody (AA 481-589)

Catalog No. ABIN674484

Product Details anti-CHRM3 Antibody

Target: CHRM3 (Cholinergic Receptor, Muscarinic 3 (CHRM3))

Binding Specificity: AA 481-589

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRM3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Chrm3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CHRM3 antibody (ABIN674484)

Zhao, Yang, Chen, Wang, Zhang, Zhang: "Expression of M3 acetylcholine receptor in asthmatic mice and bronchial airway remodeling prediction." in: Genetics and molecular research : GMR, Vol. 15, Issue 3, (2016) (PubMed).

Ozgun-Acar, Celik-Turgut, Gazioglu, Kolak, Ozbal, Ergur, Arslan, Sen, Topcu: "Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice." in: Journal of neuroimmunology, Vol. 298, pp. 106-16, (2016) (PubMed).

Chen, Li, Zhang, Zhai, Gong, Qiang, Xue: "An ENU-induced mutation of Nrg1 causes dilated pupils and a reduction in muscarinic receptors in the sphincter pupillae." in: PLoS ONE, Vol. 6, Issue 9, pp. e25176, (2011) (PubMed).

Target Details for CHRM3

Target: CHRM3 (Cholinergic Receptor, Muscarinic 3 (CHRM3))

Alternative Name: Chrm3 (CHRM3 Products)

Synonyms: EGBRS antibody, HM3 antibody, MACHR antibody, Chrm-3 antibody, M3 antibody, M3R antibody, cholinergic receptor muscarinic 3 antibody, cholinergic receptor, muscarinic 3 antibody, cholinergic receptor, muscarinic 3, cardiac antibody, CHRM3 antibody, Chrm3 antibody

Background:

Synonyms: M3, M3R, Chrm-3, Muscarinic acetylcholine receptor M3, Mm3 mAChR, Chrm3

Background: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Gene ID: 12671

UniProt: Q9ERZ3

Pathways: Synaptic Membrane