PPP1R13B antibody (AA 901-1090)

Catalog No. ABIN674379

Product Details anti-PPP1R13B Antibody

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Binding Specificity: AA 901-1090

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R13B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ASPP1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-PPP1R13B antibody (ABIN674379)

Xie, Yang, Chi, Yang, Wang, Xu: "Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study." in: Chinese journal of cancer, Vol. 36, Issue 1, pp. 15, (2017) (PubMed).

Target Details for PPP1R13B

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Alternative Name: ASPP1 (PPP1R13B Products)

Background:

Synonyms: p53BP2 like, p85, PPP1R13B, apoptosis stimulating protein of P53 1, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51.

Background: iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFKap B-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFKap B (RelA),3 interacts with NFKap B in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFKap b and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. Alternate Names: apoptosis stimulating protein of P53 1, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51.

Gene ID: 23368

UniProt: Q96KQ4

Pathways: p53 Signaling