SCRIB antibody (AA 172-409)

Catalog No. ABIN7354662

Product Details anti-SCRIB Antibody

Target: SCRIB (Scribbled Homolog (SCRIB))

Binding Specificity: AA 172-409

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCRIB antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purpose: Rabbit IgG Polyclonal Anti-Human SCRIBBLE Antibody DyLight® 550 Conjugated, Flow Validated.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG Polyclonal Anti-Human SCRIBBLE Antibody DyLight® 550 Conjugated, Flow Validated.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human SCRIBBLE recombinant protein (Position: F172-K409).

Isotype: IgG

Application Details

Application Notes:

Application details: Flow Cytometry|1-3 μg/1x106 cells

Comment:

Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: At 2-8°C for one year. Protect from light. Do not freeze.

Target Details for SCRIB

Target: SCRIB (Scribbled Homolog (SCRIB))

Alternative Name: SCRIB (SCRIB Products)

Background:

Synonyms: Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL

Background: SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis.

Gene ID: 23513

UniProt: Q14160

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Tube Formation, Synaptic Vesicle Exocytosis, Asymmetric Protein Localization