Adiponectin Receptor 2 antibody (AA 315-340)

Catalog No. ABIN670851

Product Details anti-Adiponectin Receptor 2 Antibody

Target: Adiponectin Receptor 2 (ADIPOR2)

Binding Specificity: AA 315-340

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adiponectin Receptor 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody may cross react with Adiponectin receptor 1 due to sequence similarity.

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Adiponectin receptor 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Adiponectin Receptor 2 antibody (ABIN670851)

Morad, Abrahamsson, Dabrosin: "Estradiol affects extracellular leptin:adiponectin ratio in human breast tissue in vivo." in: The Journal of clinical endocrinology and metabolism, Vol. 99, Issue 9, pp. 3460-7, (2014) (PubMed).

Ji, Wu, Ma, Ma, Qin: "The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy." in: Molecular biology reports, Vol. 41, Issue 4, pp. 2151-9, (2014) (PubMed).

Guo, Qin, Zhang, Li, Yin: "Effect of rosiglitazone on the expression of cardiac adiponectin receptors and NADPH oxidase in type 2 diabetic rats." in: European journal of pharmacology, Vol. 685, Issue 1-3, pp. 116-25, (2012) (PubMed).

Liu, Wu, Zhang, Chen, Liu, Wu, Zhu: "The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats." in: European journal of pharmacology, Vol. 650, Issue 1, pp. 384-9, (2010) (PubMed).

Target Details for Adiponectin Receptor 2

Target: Adiponectin Receptor 2 (ADIPOR2)

Alternative Name: Adiponectin receptor 2 (ADIPOR2 Products)

Synonyms: MGC84736 antibody, ADIPOR2 antibody, paqr2 antibody, acdcr2 antibody, LOC100220214 antibody, ACDCR2 antibody, PAQR2 antibody, 1110001I14Rik antibody, ADCR2 antibody, AI115388 antibody, AW554121 antibody, D6Ucla1e antibody, Paqr2 antibody, si:ch211-281k12.9 antibody, zgc:136273 antibody, adiponectin receptor 2 L homeolog antibody, adiponectin receptor 2 antibody, adipor2.L antibody, ADIPOR2 antibody, adipor2 antibody, Adipor2 antibody

Background:

Synonyms: PAQR2, ACDCR2, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II, ADIPOR2

Background: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.

Gene ID: 79602

UniProt: Q86V24

Pathways: AMPK Signaling