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CDK5 antibody (AA 15-100)

CDK5 Reactivity: Human, Mouse, Rat WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN670101
  • Target See all CDK5 Antibodies
    CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
    Binding Specificity
    • 30
    • 16
    • 15
    • 13
    • 10
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 15-100
    Reactivity
    • 125
    • 104
    • 102
    • 17
    • 15
    • 15
    • 13
    • 12
    • 12
    • 12
    • 9
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 112
    • 30
    Rabbit
    Clonality
    • 114
    • 28
    Polyclonal
    Conjugate
    • 73
    • 8
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This CDK5 antibody is un-conjugated
    Application
    • 121
    • 40
    • 38
    • 38
    • 38
    • 22
    • 20
    • 18
    • 17
    • 9
    • 8
    • 4
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody will detect both isoform variants of this protein. Due to similar amino acid composition of this protein to CDK3 in human, there is a chance that this antibody will react with CDK3 in human, based on an 83 % sequence similarity.
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Cow,Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CDK5
    Isotype
    IgG
    Top Product
    Discover our top product CDK5 Primary Antibody
  • Application Notes
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Cao, Jia, Wei, Liu, Liu, Li: "Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ1-42." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 6840432, (2016) (PubMed).

    Yin, Qi, Ren, Wang, Jiang, Feng, Cui: "Roscovitine treatment caused impairment of fertilizing ability in mice." in: Toxicology letters, Vol. 237, Issue 3, pp. 200-9, (2015) (PubMed).

    Li, Wang, Guo, Huang, Zhao, Zhu, Ma, Liang, Zhang, Huang, Wan: "Protective effect of Xingnaojia formulation on rats with brain and liver damage caused by chronic alcoholism." in: Experimental and therapeutic medicine, Vol. 10, Issue 5, pp. 1643-1652, (2015) (PubMed).

  • Target
    CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
    Alternative Name
    CDK5 (CDK5 Products)
    Synonyms
    PSSALRE antibody, AW048668 antibody, Crk6 antibody, CDK5 antibody, CG8203 antibody, DmCdk5 antibody, Dmel\\CG8203 antibody, cdk5 antibody, zgc:101604 antibody, cyclin dependent kinase 5 antibody, cyclin-dependent kinase 5 antibody, Cyclin-dependent kinase 5 antibody, cyclin-dependent kinase 5 L homeolog antibody, Cyclin-dependent-like kinase 5 antibody, CDK5 antibody, Cdk5 antibody, cdk5 antibody, cdk5.L antibody, cdk-5 antibody
    Background

    Synonyms: PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5, CDKN5

    Background: CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development, phosphorylates synaptic protein Pctaire1, regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.

    Gene ID
    1020
    UniProt
    Q00535
    Pathways
    Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
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