SLC1A5 antibody (AA 465-515)

Catalog No. ABIN669081

Product Details anti-SLC1A5 Antibody

Target: SLC1A5 (Solute Carrier Family 1 Member 5 (SLC1A5))

Binding Specificity: AA 465-515

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC1A5 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLC1A5

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SLC1A5 antibody (ABIN669081)

Díaz-Carballo, Klein, Acikelli, Wilk, Saka, Jastrow, Wennemuth, Dammann, Giger-Pabst, Khosrawipour, Rassow, Nienen, Strumberg: "Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells." in: Oncotarget, Vol. 8, Issue 56, pp. 95945-95964, (2017) (PubMed).

Huang, Zhao, Zhao, Wu, Jiang, Ma, Zhang: "Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer." in: International journal of clinical and experimental pathology, Vol. 7, Issue 9, pp. 6006-14, (2014) (PubMed).

Target Details for SLC1A5

Target: SLC1A5 (Solute Carrier Family 1 Member 5 (SLC1A5))

Alternative Name: SLC1A5 (SLC1A5 Products)

Synonyms: aaat antibody, asct2 antibody, atbo antibody, m7v1 antibody, m7vs1 antibody, r16 antibody, rdrc antibody, AAAT antibody, ASCT2 antibody, ATBO antibody, M7V1 antibody, M7VS1 antibody, R16 antibody, RDRC antibody, Slc1a7 antibody, Asct2 antibody, H4-ASCT2 antibody, solute carrier family 1 (neutral amino acid transporter), member 5 antibody, solute carrier family 1 member 5 S homeolog antibody, solute carrier family 1 member 5 antibody, slc1a5 antibody, slc1a5.S antibody, SLC1A5 antibody, Slc1a5 antibody

Background:

Synonyms: R16, AAAT, ATBO, M7V1, RDRC, ASCT2, M7VS1, Neutral amino acid transporter B(0), ATB(0), Baboon M7 virus receptor, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5, SLC1A5, RDR

Background: Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).

Gene ID: 6510

UniProt: Q15758

Pathways: Dicarboxylic Acid Transport, Warburg Effect