Thyroperoxidase antibody (AA 351-450)

Catalog No. ABIN668736

Product Details anti-Thyroperoxidase Antibody

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Binding Specificity: AA 351-450

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Thyroid peroxidase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: Thyroid peroxidase (TPO Products)

Synonyms: MSA antibody, TDH2A antibody, TPX antibody, TPO antibody, msa antibody, tpx antibody, xtpo antibody, LOC100218312 antibody, thyroid peroxidase antibody, TPO antibody, Tpo antibody, tpo antibody, LOC100547103 antibody

Background:

Synonyms: Thyroid peroxidase, TPO

Background: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].

Gene ID: 22018

UniProt: P35419

Pathways: Thyroid Hormone Synthesis