WNK4 antibody (Cy3)
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- Target See all WNK4 Antibodies
- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This WNK4 antibody is conjugated to Cy3
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Mouse
- Predicted Reactivity
- Human,Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human WNK4
- Isotype
- IgG
- Top Product
- Discover our top product WNK4 Primary Antibody
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- Application Notes
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
- Alternative Name
- WNK4 (WNK4 Products)
- Synonyms
- WNK4 antibody, PHA2B antibody, PRKWNK4 antibody, 2010002J11Rik antibody, Pha2b antibody, Prkwnk4 antibody, Ac2-059 antibody, WNK lysine deficient protein kinase 4 antibody, WNK4 antibody, Wnk4 antibody
- Background
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Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.
Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.
- Gene ID
- 65266
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