WNK4 antibody (AA 351-450)

Catalog No. ABIN668526

Product Details anti-WNK4 Antibody

Target: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Binding Specificity: AA 351-450

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNK4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WNK4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for WNK4

Target: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Alternative Name: WNK4 (WNK4 Products)

Synonyms: WNK4 antibody, PHA2B antibody, PRKWNK4 antibody, 2010002J11Rik antibody, Pha2b antibody, Prkwnk4 antibody, Ac2-059 antibody, WNK lysine deficient protein kinase 4 antibody, WNK4 antibody, Wnk4 antibody

Background:

Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.

Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.

Gene ID: 65266