NREP antibody (AA 25-68)

Catalog No. ABIN668496

Product Details anti-NREP Antibody

Target: NREP (C5orf13) (Chromosome 5 Open Reading Frame 13 (C5orf13))

Binding Specificity: AA 25-68

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NREP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human P311

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-NREP antibody (ABIN668496)

Li, Yao, He, Gao, Bai, Yang, Zhang, Zhan, Tan, Zhou, Takata, Wu, Luo: "P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression." in: Stem cell research & therapy, Vol. 7, Issue 1, pp. 175, (2016) (PubMed).

Yao, Li, He, Yang, Zhang, Zhan, Xu, Tan, Zhou, Wu, Luo: "P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 Activation." in: Stem cells and development, Vol. 26, Issue 6, pp. 451-460, (2016) (PubMed).

Yao, Yang, He, Li, Xu, Zhang, Li, Zhan, Sun, Tan, Zhou, Luo, Wu: "P311 promotes renal fibrosis via TGFβ1/Smad signaling." in: Scientific reports, Vol. 5, pp. 17032, (2015) (PubMed).

Yan, Zhang, Wang, Xu, Ren, Zhang, Shi, Chen, Shi, Tian, Zhao, Dong: "Significant reduction of the GLUT3 level, but not GLUT1 level, was observed in the brain tissues of several scrapie experimental animals and scrapie-infected cell lines." in: Molecular neurobiology, Vol. 49, Issue 2, pp. 991-1004, (2014) (PubMed).

Peng, Yuan, Tan, Ma, Bian, Xu, He, Cao, Huang, Cui, Gan, Wang, Zhou, Hu, Yang, Luo, Wu: "Identification of ITGB4BP as a new interaction protein of P311." in: Life sciences, Vol. 90, Issue 15-16, pp. 585-90, (2012) (PubMed).

Target Details for NREP

Target: NREP (C5orf13) (Chromosome 5 Open Reading Frame 13 (C5orf13))

Alternative Name: P311 protein (C5orf13 Products)

Synonyms: 3.1 antibody, CZH5orf13 antibody, NREP antibody, C5orf13 antibody, D4S114 antibody, P311 antibody, PRO1873 antibody, PTZ17 antibody, SEZ17 antibody, AI325076 antibody, D0H4S114 antibody, Harp antibody, neuronal regeneration related protein antibody, NREP antibody, Nrep antibody

Background:

Synonyms: P311, PTZ17, SEZ17, D4S114, C5orf13, PRO1873, Neuronal regeneration-related protein, Neuronal protein 3.1, Protein p311, NREP

Background: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Gene ID: 9315

UniProt: Q16612