PCDHGA1 antibody (AA 808-931)

Catalog No. ABIN6657934

Product Details anti-PCDHGA1 Antibody

Target: PCDHGA1 (Protocadherin gamma A1 (PCDHGA1))

Binding Specificity: AA 808-931

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PCDHGA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Purpose: Protocadherin Gamma (pan) Antibody

Cross-Reactivity (Details): BLAST analysis suggests that it is 99 % identical to human.

Purification: Anti-Protocadherin Gamma (pan) Antibody was purified from concentrated tissue culture supernate by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: Anti-Protocadherin Gamma (pan) Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 808-931 of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins.

Clone: S159-5

Isotype: IgG1

Application Details

Application Notes:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Other: ICC/IF: 1:100

Comment:

Anti-Protocadherin Gamma (pan) Antibody is tested for Western Blots and Immunocytochemistry. Expect a band approximately ~100 kDa on specific lysates or tissues. It will cross react with all Gamma-protocadherins -A, -B, and -C. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.1 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for PCDHGA1

Target: PCDHGA1 (Protocadherin gamma A1 (PCDHGA1))

Alternative Name: Pcdhga1 (PCDHGA1 Products)

Synonyms: PCDH-GAMMA-A1 antibody, protocadherin gamma subfamily A, 1 antibody, protocadherin gamma-C5 antibody, PCDHGA1 antibody, LOC478038 antibody, Pcdhga1 antibody

Background:

Synonyms: PCDH, Protocadherin Gamma antibody, PCDH gamma antibody, PCDH-gamma, PCDHG, Protocadherin gamma , Protocadherin gamma, Gamma Protocadherin (pan), Pan-Gamma-Protocadherin, Pan Gamma Protocadherin

Background: The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. Anti-Protocadherin Gamma (pan) is ideal for research in Neuroscience, Cell Adhesion and Cell Signaling.

Gene Name: Protocadherin-Gamma-A1

Gene ID: 93709

UniProt: Q91XZ0