SETD1A antibody (Internal Region, N-Term)

Catalog No. ABIN6657812

Supplier Product No.: 100-401-v94

Product Details anti-SETD1A Antibody

Target: SETD1A (SET Domain Containing 1A (SETD1A))

Binding Specificity: Internal Region, N-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETD1A antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Supplier Product No.: 100-401-v94

Supplier: Rockland

Purpose: Setd1a Antibody

Cross-Reactivity (Details): Cross reactivity with Setd1a from other species not tested.

Purification: Anti-Setd1a Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Sterility: Sterile filtered

Immunogen: Anti-Setd1a Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides of mouse Setd1a: two containing an amino acid sequence from the N-terminal region of the protein and one containing an amino acid sequence from the internal region of the protein.

Isotype: IgG

Application Details

Application Notes:

ELISA_Dilution: 1:100

Western_Blot_Dilution: 1:500

Comment:

Anti-Setd1a Antibody has been tested by ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 186 kDa in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for SETD1A

Target: SETD1A (SET Domain Containing 1A (SETD1A))

Alternative Name: Setd1a (SETD1A Products)

Background:

Synonyms: Histone-lysine N-methyltransferase SETD1A, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, hSET1A, Set1/Ash2 histone methyltransferase complex subunit SET1

Background: SETD1A is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1A shows a non-overlapping localization with SETD1B, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression. Anti-Setd1a Antibody is ideal for research in Epigenetics and Gene Expression.

Gene Name: SETD1A

Gene ID: 9739

NCBI Accession: NP_055527

UniProt: E9PYH6