KCNQ1 antibody (N-Term)

Catalog No. ABIN6656737

Supplier Product No.: 200-301-f82

The Mouse Monoclonal anti-KCNQ1 antibody has been validated for WB, IHC, IP, IF and FM. It is suitable to detect KCNQ1 in samples from Human.

Quick Overview for KCNQ1 antibody (N-Term) (ABIN6656737)

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNQ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Fluorescence Microscopy (FM)

Clone: N37A-10

Product Details anti-KCNQ1 Antibody

Binding Specificity: N-Term

Supplier Product No.: 200-301-f82

Supplier: Rockland

Purpose: KCNQ1 Antibody

Cross-Reactivity (Details): A BLAST analysis was used to suggest cross-reactivity with KCNQ1 from Human, Rat, and Mouse based on 100 % homology with the immunizing sequence.

Purification: Anti-KCNQ1 Antibody was purified by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: KCNQ1 Antibody was produced in mice by repeated immunizations raised against a fusion protein n-terminal region of human KCNQ1.

Isotype: IgG1

Application Details

Application Notes:

Immunohistochemistry_Dilution: 0.1-1.0 μg/mL

IF_Microscopy_Dilution: 1.0-10 μg/mL

Western_Blot_Dilution: 1-10 μg/mL

Comment:

Anti-KCNQ1 Antibody is tested for use in WB, IP, IF, and IHC. Expect a band approximately ~75kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for KCNQ1

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Alternative Name: KCNQ1

Background:

Synonyms: ATFB1, JLNS1, KCNA8, KCNA9, Kv1.9, Kv7.1, KVLQT1, LQT, LQT1, RWS, SQT2, voltage gated potassium channel subunit KV7.1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Potassium voltage-gated channel subfamily KQT member 1

Background: Specifically, Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction.

Gene Name: KCNQ1

Gene ID: 3784

NCBI Accession: NP_000209

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound