KDELR1 antibody

Catalog No. ABIN6656145

Supplier Product No.: 600-401-f85

Product Details anti-KDELR1 Antibody

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDELR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Supplier Product No.: 600-401-f85

Supplier: Rockland

Purpose: KDEL Antibody

Cross-Reactivity (Details): A BLAST analysis was used to suggest cross-reactivity with KDEL from Human, Mouse, and Rat based on 100 % homology with the immunizing sequence.

Purification: Anti-KDEL Antibody was purified by affinity chromatography.

Sterility: Sterile filtered

Immunogen: KDEL Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against KDEL containing synthetic peptide immunogen.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-KDEL Antibody is tested for use in WB, IF, and IHC. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for KDELR1

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Alternative Name: KDELR1 (KDELR1 Products)

Background:

Synonyms: Lys Asp Glu Leu, K-D-E-L, ER lumen protein retaining receptor 1, KDEL endoplasmic reticulum protein retention, Kdelr1

Background: The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER.

Gene Name: Kdelr1

Gene ID: 10945

NCBI Accession: NP_006792

UniProt: P24390

Pathways: Maintenance of Protein Location