KDM5C antibody

Catalog No. ABIN6655941

Supplier Product No.: 100-401-w42

Product Details anti-KDM5C Antibody

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM5C antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Supplier Product No.: 100-401-w42

Supplier: Rockland

Purpose: JARID1C Antibody

Cross-Reactivity (Details): Cross reactivity with Jarid1c from other species not tested.

Purification: Anti-Jarid1c Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Sterility: Sterile filtered

Immunogen: Anti-JARID1C Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides containing sequences from the inner part of the mouse Jarid1c protein.

Isotype: IgG

Application Details

Application Notes:

ELISA_Dilution: 1:500

Western_Blot_Dilution: 1:1,000

Comment:

Anti-JARID1C Antibody has been tested by ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 175 kDa in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Alternative Name: Jarid1c (KDM5C Products)

Background:

Synonyms: Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, DXS1272E, JARID1C, SMCX, XE169

Background: Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a internal role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation. Anti-Jarid1c Antibody is ideal for research in Epigenetics, Gene Expression and Neuroscience.

Gene Name: KDM5C

Gene ID: 8242

NCBI Accession: NP_001140174

UniProt: P41229

Pathways: Warburg Effect