BAZ2A antibody

Catalog No. ABIN6655926

Supplier Product No.: 100-401-v86

Product Details anti-BAZ2A Antibody

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAZ2A antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Supplier Product No.: 100-401-v86

Supplier: Rockland

Purpose: TIP5 Antibody

Cross-Reactivity (Details): Cross reactivity with TIP5 from other species not tested.

Purification: Anti-TIP5 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Sterility: Sterile filtered

Immunogen: Anti-TIP5 Antibody was produced in rabbits by repeated immunizations with a recombinant protein of human TIP5.

Isotype: IgG

Application Details

Application Notes:

ChIP_Dilution: 5 μL/ChIP

Western_Blot_Dilution: 1:1,000

Comment:

Anti-TIP5 Antibody has been tested by ChIP and Western Blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 250 kDa in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for BAZ2A

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Alternative Name: TIP5 (BAZ2A Products)

Background:

Synonyms: Bromodomain adjacent to zinc finger domain protein 2A, Transcription termination factor I-interacting protein 5, TTF-I-interacting protein 5, hWALp3

Background: TIP 5 is the large subunit of the nucleolar remodeling complex NoRC. NoRC causes the repression of ribosomal gene transcription. It was demonstrated that histone deacetylation is involved in this repression and that TIP5 is associated with the histone deacetylase HDAC1 and mediates the deacetylation of histones in the vicinity of the rDNA promoter. The interaction of TIP5 and HDAC1, which is necessary for transcriptional repression, is established by the C-terminal PHD finger and bromodomain. Anti-TIP5 Antibody is ideal for research in Gene Expression.

Gene Name: BAZ2A

Gene ID: 11176

NCBI Accession: NP_038477

UniProt: Q9UIF9