DUX4 antibody (C-Term)

Catalog No. ABIN6655475

Supplier Product No.: 209-301-f23

Product Details anti-DUX4 Antibody

Target: DUX4 (Double Homeobox 4 (DUX4))

Binding Specificity: C-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DUX4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Fluorescence Microscopy (FM)

Supplier Product No.: 209-301-f23

Supplier: Rockland

Purpose: DUX4 Antibody

Cross-Reactivity (Details): This monoclonal antibody is specific for human DUX4 protein.

Purification: Anti-DUX4 Antibody was purified by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: DUX4 Antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to the C-terminal region of human DUX4 protein.

Clone: P2B1

Isotype: IgG1

Application Details

Application Notes:

Immunohistochemistry_Dilution: User Optimized

IF_Microscopy_Dilution: User Optimized

Western_Blot_Dilution: 1:1000

Comment:

Anti-DUX4 Antibody is tested for use in WB and IF and suitable for IHC. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for DUX4

Target: DUX4 (Double Homeobox 4 (DUX4))

Alternative Name: DUX4 (DUX4 Products)

Background:

Synonyms: mouse anti-DUX4 Antibody, double homeobox 4, DUX4, Double homeobox protein 4-like protein, DUX4L2, DUX4L3, DUX4L5, DUX4L6, DUX4L7

Background: DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1. Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function. In FSHD individuals, the expression of the full-length DUX4 transcipt is not completely suppressed in skeletal muscle and possibly other differentiated tissues.

Gene Name: DUX2

Gene ID: 100288687

NCBI Accession: NP_001280727

UniProt: Q9UBX2