ACP5 antibody
-
- Target See all ACP5 Antibodies
- ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
-
Reactivity
- Human, Mouse, Rat
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This ACP5 antibody is un-conjugated
-
Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- Purified
- Purity
- Protein G affinity chromatography
- Immunogen
- Recombinant full-length human protein was used as the immunogen for the recombinant TRAcP antibody.
- Clone
- RACP5-1070
- Isotype
- IgG1
- Top Product
- Discover our top product ACP5 Primary Antibody
-
-
- Application Notes
-
Optimal dilution of the recombinant TRAcP antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT
- Restrictions
- For Research Use only
-
- Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- Preservative
- Azide free
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store the recombinant TRAcP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
-
- Target
- ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
- Alternative Name
- TRAcP / TRAP / ACP5 (ACP5 Products)
- Synonyms
- SPENCDI antibody, TRAP antibody, acp5 antibody, sb:cb576 antibody, zgc:63825 antibody, wu:fb19f01 antibody, wu:fb30b03 antibody, wu:fi14e01 antibody, wu:fj66f03 antibody, MGC78938 antibody, MGC89674 antibody, TR-AP antibody, zgc:92339 antibody, TRACP antibody, TTRRAP antibody, Trap antibody, UF antibody, acid phosphatase 5, tartrate resistant antibody, acid phosphatase 5a, tartrate resistant antibody, acid phosphatase 5, tartrate resistant S homeolog antibody, tartrate resistant acid phosphatase antibody, Tartrate-resistant acid phosphatase type 5 antibody, tartrate-resistant acid phosphatase type 5 antibody, acid phosphatase 5b, tartrate resistant antibody, ACP5 antibody, acp5a antibody, acp5.S antibody, acp5 antibody, NAEGRDRAFT_81291 antibody, ppa5 antibody, LOC100282899 antibody, acp5b antibody, Acp5 antibody
- Background
- It recognizes a protein of 35 kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
- Pathways
- Transition Metal Ion Homeostasis
-