CD44v3 antibody
Reactivity: Human
IHC (p)
Host: Mouse
Monoclonal
3G5
unconjugated
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- Target
- CD44v3
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- Purified
- Purity
- Protein G affinity chromatography
- Immunogen
- An amino acid sequence from the variant 3 domain of CD44 was used as the immunogen for the CD44v3 antibody.
- Clone
- 3G5
- Isotype
- IgG1 kappa
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- Application Notes
- Titering of the CD44v3 antibody may be required for optimal performance.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT
- Restrictions
- For Research Use only
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- Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- Preservative
- Azide free
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store the CD44v3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Target
- CD44v3
- Background
- This antibody recognizes an epitope encoded by exon v3 on the variant portion of human CD44. The CD44 Molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. It is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.
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