IL36A/IL1F6 antibody (AA 6-151)

Catalog No. ABIN6654183

Product Details anti-IL36A/IL1F6 Antibody

Target: IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

Binding Specificity: AA 6-151

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL36A/IL1F6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: Human IL-36 alpha recombinant protein (amino acids K6-D151) was used as the immunogen for the IL36A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the IL36A antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL,ELISA (capture): 1-5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the IL36A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for IL36A/IL1F6

Target: IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

Alternative Name: IL-36 alpha / IL-1F6 (IL1F6 Products)

Synonyms: Il1f6 antibody, Fil1 antibody, IL-1H1 antibody, IL1RP2 antibody, Il1f9 antibody, Il36a antibody, FIL1 antibody, FIL1(EPSILON) antibody, FIL1E antibody, IL-1F6 antibody, IL1(EPSILON) antibody, IL1F6 antibody, interleukin 36, alpha antibody, interleukin 1 family, member 6 (epsilon) antibody, interleukin 1 family, member 6 antibody, interleukin 36 alpha antibody, Il36a antibody, IL1F6 antibody, IL36A antibody, Il1f6 antibody

Background: Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene. The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients.

UniProt: Q9UHA7

Pathways: Cancer Immune Checkpoints