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Thrombomodulin antibody
THBD
Reactivity: Human, Rabbit
FACS, IHC (p), IHC (fro)
Host: Mouse
Monoclonal
QBEND-40
unconjugated
Product Details anti-Thrombomodulin Antibody
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Target
See all Thrombomodulin (THBD) Antibodies
Thrombomodulin (THBD)
Reactivity
All reactivities for Thrombomodulin antibodies
Human, Rabbit
Host
All hosts for Thrombomodulin antibodies
Mouse
Clonality
All clonalities for Thrombomodulin antibodies
Monoclonal
Conjugate
All conjugates for Thrombomodulin antibodies
This Thrombomodulin antibody is un-conjugated
Application
All applications for Thrombomodulin antibodies
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
Purification
Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum
Immunogen
Human Endothelium (Thrombomodulin).
Clone
QBEND-40
Isotype
IgG2a
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody undiluted at -20 °C.
Target Details for Thrombomodulin
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Target
Thrombomodulin (THBD)
Alternative Name
CD141 / THBD (THBD Products )
Synonyms
AHUS6 antibody, BDCA3 antibody, CD141 antibody, THPH12 antibody, THRM antibody, TM antibody, AI385582 antibody, THBD antibody, HAST antibody, HAST3 antibody, M-PST antibody, ST1A3/ST1A4 antibody, ST1A5 antibody, STM antibody, TL-PST antibody, thrombomodulin antibody, sulfotransferase family 1A member 3 antibody, THBD antibody, Thbd antibody, SULT1A3 antibody
Background
CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII, thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.Synonyms: Fetomodulin, THRM, Thrombomodulin
Gene ID
9606
UniProt
P07204
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