CELA2A antibody (C-Term)

Catalog No. ABIN657926

Product Details anti-CELA2A Antibody

Target: CELA2A (Chymotrypsin-Like Elastase Family, Member 2A (CELA2A))

Binding Specificity: AA 231-260, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CELA2A antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CELA2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human CELA2A.

Clone: RB33880

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: CELA2A Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-CELA2A antibody (ABIN657926)

Guihard, Yao, Blazquez-Medela, Iruela-Arispe, Boström, Yao: "Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice." in: PLoS ONE, Vol. 11, Issue 12, pp. e0167936, (2017) (PubMed).

Yao, Guihard, Blazquez-Medela, Guo, Moon, Jumabay, Boström, Yao: "Serine Protease Activation Essential for Endothelial-Mesenchymal Transition in Vascular Calcification." in: Circulation research, Vol. 117, Issue 9, pp. 758-69, (2015) (PubMed).

Target Details for CELA2A

Target: CELA2A (Chymotrypsin-Like Elastase Family, Member 2A (CELA2A))

Alternative Name: CELA2A (CELA2A Products)

Background: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.

Molecular Weight: 28888

Gene ID: 63036

NCBI Accession: NP_254275

UniProt: P08217