p63 antibody (C-Term)

Catalog No. ABIN657886

Product Details anti-p63 Antibody

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Binding Specificity: AA 651-680, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p63 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from the C-terminal region of human TP63.

Clone: RB30257

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: TP63 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-p63 antibody (ABIN657886)

Zamudio, Wang, Chung, Wolosin: "Inhibition of TGF? cell signaling for limbal explant culture in serumless, defined xeno-free conditions." in: Experimental eye research, Vol. 145, pp. 48-57, (2015) (PubMed).

Target Details for p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Alternative Name: TP63 (TP63 Products)

Background: This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Molecular Weight: 76785

Gene ID: 8626

NCBI Accession: NP_001108450, NP_001108451, NP_001108452, NP_001108453, NP_001108454, NP_003713

UniProt: Q9H3D4