This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This HIST2H2AA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human HIST2H2AA3.
H2A antibody, H2A.2 antibody, H2A/O antibody, H2A/q antibody, H2AFO antibody, H2a-615 antibody, HIST2H2AA antibody, Hist2h2aa antibody, Hist2h2aa1 antibody, histone cluster 2 H2A family member a3 antibody, histone cluster 2 H2A family member A3 antibody, HIST2H2AA3 antibody, Hist2h2aa3 antibody
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated, this record represents the centromeric copy.