PCDHGA3 antibody (AA 284-311)

Catalog No. ABIN657534

Product Details anti-PCDHGA3 Antibody

Target: PCDHGA3 (PCDHgA3) (Protocadherin gamma A3 (PCDHgA3))

Binding Specificity: AA 284-311

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGA3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PCDHGA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-311 amino acids from the Central region of human PCDHGA3.

Clone: RB33029

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: PCDHGA3 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-PCDHGA3 antibody (ABIN657534)

Zhang, Takata, Cui, Miyata-Takata, Sato, Noujima-Harada, Yoshino: "Protocadherin γ A3 is expressed in follicular lymphoma irrespective of BCL2 status and is associated with tumor cell growth." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4622-4628, (2017) (PubMed).

Target Details for PCDHGA3

Target: PCDHGA3 (PCDHgA3) (Protocadherin gamma A3 (PCDHgA3))

Alternative Name: PCDHGA3 (PCDHgA3 Products)

Synonyms: PCDH-GAMMA-A3 antibody, protocadherin gamma subfamily A, 3 antibody, PCDHGA3 antibody, Pcdhga3 antibody

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Molecular Weight: 100971

Gene ID: 56112

NCBI Accession: NP_061739, NP_114400

UniProt: Q9Y5H0