FOXN4 antibody (N-Term)

Catalog No. ABIN657413

Product Details anti-FOXN4 Antibody

Target: FOXN4 (Forkhead Box N4 (FOXN4))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXN4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FOXN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FOXN4.

Clone: RB33396

Isotype: Ig Fraction

Product Specific Information:

What can IL-6 ELISA Kit ABIN6574135 be used for? This mouse IL-6 ELISA Kit is suitable for the reliable detection of IL6 / Interleukin 6 in cell culture supernatant, cell lysate, plasma, serum and other sample types. The minimum detection limit is 7.8 pg/ml, the detection range is 7.8 pg/ml to 500 pg/ml.

What validation data is available for this IL-6 ELISA kit? 5 images are available that show the performance of the kit components. The kit is cited in 49 PubMd publications. Use our high quality IL6 ELISA kit for the reliable detection of IL-6.

What is the function of IL6? Interleukin 6 (IL-6) is a protein that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. It is encoded by the IL6 gene in humans. Osteoblasts secrete IL-6 to stimulate the formation of osteoclasts. Additionally, smooth muscle cells in the tunica media of many blood vessels produce IL-6 as a pro-inflammatory cytokine. IL-6 acts as an anti-inflammatory myokine by inhibiting TNF-alpha and IL-1 and activating IL-1ra and IL-10.

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: FOXN4 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for FOXN4

Target: FOXN4 (Forkhead Box N4 (FOXN4))

Alternative Name: FOXN4 (FOXN4 Products)

Background: Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM].

Molecular Weight: 55215

Gene ID: 121643

NCBI Accession: NP_998761

UniProt: Q96NZ1