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ERO1L antibody (C-Term)

ERO1L Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB33290 unconjugated
Catalog No. ABIN657228
  • Target See all ERO1L Antibodies
    ERO1L (ERO1-Like Protein alpha (ERO1L))
    Binding Specificity
    • 16
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 350-379, C-Term
    Reactivity
    • 43
    • 4
    • 4
    Human
    Host
    • 37
    • 5
    • 1
    Rabbit
    Clonality
    • 40
    • 2
    Polyclonal
    Conjugate
    • 20
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ERO1L antibody is un-conjugated
    Application
    • 43
    • 22
    • 19
    • 16
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ERO1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-379 amino acids from the C-terminal region of human ERO1L.
    Clone
    RB33290
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ERO1L Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    ERO1L (ERO1-Like Protein alpha (ERO1L))
    Alternative Name
    ERO1L (ERO1L Products)
    Synonyms
    ERO1-L antibody, ero1-alpha antibody, ero1lb antibody, ERO1L antibody, ero1l antibody, ERO1-alpha antibody, ERO1A antibody, zgc:63959 antibody, endoplasmic reticulum oxidoreductase alpha L homeolog antibody, endoplasmic reticulum oxidoreductase 1 alpha antibody, endoplasmic reticulum oxidoreductase alpha antibody, ERO1-like (S. cerevisiae) antibody, ero1a.L antibody, ERO1A antibody, ero1a antibody, Ero1l antibody, Ero1a antibody
    Background
    Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.
    Molecular Weight
    54393
    NCBI Accession
    NP_055399
    UniProt
    Q96HE7
    Pathways
    Peptide Hormone Metabolism, ER-Nucleus Signaling, Brown Fat Cell Differentiation
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