CTPS2 antibody (C-Term)

Catalog No. ABIN656954

Product Details anti-CTPS2 Antibody

Target: CTPS2 (CTP Synthase II (CTPS2))

Binding Specificity: AA 450-479, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTPS2 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human CTPS2.

Clone: RB32822

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: CTPS2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for CTPS2

Target: CTPS2 (CTP Synthase II (CTPS2))

Alternative Name: CTPS2 (CTPS2 Products)

Synonyms: A830031M15Rik antibody, AI326475 antibody, Ctpsh antibody, CTP synthase 2 L homeolog antibody, CTP synthase 2 antibody, cytidine 5'-triphosphate synthase 2 antibody, ctps2.L antibody, CTPS2 antibody, ctps2 antibody, Ctps2 antibody

Background: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

Molecular Weight: 65678

Gene ID: 56474

NCBI Accession: NP_001137474, NP_062831, NP_787055

UniProt: Q9NRF8

Pathways: Ribonucleoside Biosynthetic Process