NUDT1 antibody
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- Target See all NUDT1 Antibodies
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NUDT1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- This antibody ist KO validated.
- Purification
- Affinity purification
- Grade
- KO Validated
- Immunogen
- Recombinant fusion protein of human NUDT1 (NP_945192.1).
- Isotype
- IgG
- Top Product
- Discover our top product NUDT1 Primary Antibody
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- Alternative Name
- NUDT1 (NUDT1 Products)
- Synonyms
- mutT antibody, nudT1 antibody, MTH1 antibody, Mth1 antibody, 7,8-dihydro-8-oxoguanine triphosphatase antibody, nudix hydrolase 1 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 1 antibody, mth1 antibody, Tsp_07498 antibody, nudt1 antibody, 8odp antibody, NUDT1 antibody, Nudt1 antibody
- Background
- Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
- Molecular Weight
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Observed_MW: Refer to Figures
Calculated_MW: 17kDa/19kDa/20kDa/22kDa
- Gene ID
- 4521
- UniProt
- P36639
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