DYNC2H1 antibody

Catalog No. ABIN6567791

Product Details anti-DYNC2H1 Antibody

Target: DYNC2H1 (Dynein, Cytoplasmic 2, Heavy Chain 1 (DYNC2H1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNC2H1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant Protein of human DYNC2H1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DYNC2H1

Target: DYNC2H1 (Dynein, Cytoplasmic 2, Heavy Chain 1 (DYNC2H1))

Alternative Name: DYNC2H1 (DYNC2H1 Products)

Background:

Synonyms: Cytoplasmic dynein 2 heavy chain 1,Cytoplasmic dynein 2 heavy chain,DYHC2,DYNC2H1,Dynein cytoplasmic heavy chain 2,Dynein heavy chain 11,Dynein heavy chain isotype 1B,hDHC11

Background: This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Molecular Weight:

Observed_MW: 493kDa

Calculated_MW: 105kDa/492kDa/493kDa

Gene ID: 79659

UniProt: Q8NCM8

Pathways: Hedgehog Signaling, Asymmetric Protein Localization