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Fibrillarin antibody

FBL Reactivity: Human, Mouse, Monkey WB, IF, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6567124
  • Target See all Fibrillarin (FBL) Antibodies
    Fibrillarin (FBL)
    Reactivity
    • 49
    • 29
    • 29
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Monkey
    Host
    • 42
    • 10
    • 1
    Rabbit
    Clonality
    • 41
    • 12
    Polyclonal
    Conjugate
    • 32
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Fibrillarin antibody is un-conjugated
    Application
    • 44
    • 11
    • 11
    • 10
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human FBL
    Isotype
    IgG
    Top Product
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  • Application Notes
    WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Fibrillarin (FBL)
    Alternative Name
    FBL (FBL Products)
    Background

    Synonyms: 34 kD nucleolar scleroderma antigen,34 kDa nucleolar scleroderma antigen,Fbl,FBRL,FIB,FIB1,FLRN,Histone-glutamine methyltransferase,Nop1p,RNA U3 small nucleolar interacting protein 1,RNU3IP1,rRNA 2' O methyltransferase fibrillarin,rRNA 2'-O-methyltransferase fibrillarin

    Background: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.

    Molecular Weight

    Observed_MW: 36kDa

    Calculated_MW: 33kDa

    Gene ID
    2091
    UniProt
    P22087
    Pathways
    Ribonucleoside Biosynthetic Process
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