RASGRP1 antibody
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- Target See all RASGRP1 Antibodies
- RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RASGRP1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human RASGRP1
- Isotype
- IgG
- Top Product
- Discover our top product RASGRP1 Primary Antibody
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- Application Notes
- WB 1:1000 - 1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
- Alternative Name
- RASGRP1 (RASGRP1 Products)
- Synonyms
- Rasgrp antibody, CALDAG-GEFI antibody, CALDAG-GEFII antibody, RASGRP antibody, V antibody, hRasGRP1 antibody, RAS guanyl releasing protein 1 antibody, Rasgrp1 antibody, RASGRP1 antibody
- Background
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Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor II,CALDAG-GEFI,CalDAG-GEFII,GRP1,Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A,hRasGRP1,Ras activator RasGRP,RAS guanyl nucleotide releasing protein 1,RAS guanyl releasing protein 1 (calcium and DAG-regulated),RAS guanyl releasing protein 1,RAS guanyl-releasing protein 1,Ras guanyl-releasing protein,RASGRP,rasgrp1,V
Background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
- Molecular Weight
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Observed_MW: 90kDa
Calculated_MW: 55kDa/62kDa/68kDa/86kDa/90kDa
- Gene ID
- 10125
- UniProt
- O95267
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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